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Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy

What was once a stepwise sequence: metformin, sulfonylurea, insulin: has become a personalised choice, with classes (GLP-1 receptor agonists, SGLT2 inhibitors, dual GIP/GLP-1 agonists) chosen as much for cardiovascular and renal protection as for blood-glucose control

In 2021, the FDA approved semaglutide, known under the popular brand names Ozempic and Wegovy, for chronic weight management in adults with or overweight with at least one weight-related condition

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